Anchoring of the contractile ring
To better understand the mechanisms that anchor the contractile ring to the plasma membrane and generate the tension necessary for furrow ingression, our lab uses a combination of laser ablation, confocal microscopy, and hsFPALM. With this information, we can better understand how changes in physical properties, like drag and velocity, relate to changes in molecular organization of protein proteins.
The role of Post-Anaphase Array (PAA) microtubules in cell division
Our lab studies the role PAA microtubules play in cell division. The overall goal for the this project is to determine how the PAA microtubules connect to the contractile ring and to the nuclei and how these connections affect cell division behavior.
